High Quality Content by WIKIPEDIA articles! The Master of Science in Information Systems (MSIS), Master of Science in Management Information Systems (MSMIS) is a specialized master`s degree program usually offered in a University`s College of Business. The MSIS degree is designed for those managing information technology, especially the information systems development process. The MSIS degree is functionally equivalent to a Master of Information Systems Management, which is one of several specialized master`s degree programs recognized by the Association to Advance Collegiate Schools of Business (AACSB).