High Quality Content by WIKIPEDIA articles! Matadero Creek is a stream originating in the foothills of the Santa Cruz Mountains in Santa Clara County, California, United States. The creek flows in a northeasterly direction for 8 miles (13 km) until it enters the Palo Alto Flood Basin, then joins Adobe Creek at the north end of the Mayfield Slough before culminating in southwest San Francisco Bay. Matadero Creek begins in the city of Los Altos Hills, then traverses the Stanford University lands and Palo Alto.