High Quality Content by WIKIPEDIA articles! Melatonin receptor agonists are analogues of melatonin that bind to and activate the melatonin receptor.Agonists of the melatonin receptor have a number of therapeutic applications including treatment of sleep disorders and depression. The discovery and development of melatonin receptor agonists was motivated by the need for more potent analogues than melatonin, with better pharmacokinetics and longer half-life. Melatonin receptor agonists are analogues of melatonin and were developed with the melatonin structure as a model.