High Quality Content by WIKIPEDIA articles! Methoxetamine (MXE) or 3-MeO-2-Oxo-PCE is a chemical of the arylcyclohexylamine class which has been sold as a designer drug. It is a derivative of ketamine that also contains structural features of eticyclidine and 3-MeO-PCP. Methoxetamine is thought to behave as a NMDA receptor antagonist and dopamine reuptake inhibitor, though it has not been formally profiled pharmacologically. Methoxetamine differs from many other dissociative anesthetics of the arylcyclohexylamine class in that it was designed for grey-market distribution. Methoxetamine is a product of rational drug design: its N-ethyl group was chosen to increase potency, lessening the risk of interstitial cystitis that can result from the accumulation of ketamine-like metabolites in the urinary bladder.