Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Methoxyflurane (C3H4Cl2F2O, or 2,2-dichloro-1,1-difluoroethyl methyl ether) was commonly used as an inhalational anaesthetic in the 1960s and early 1970s. It is classified as a halogenated hydrocarbon under the ATC code N01 (Anesthetics) subgroup of the Anatomical Therapeutic Chemical Classification System, but its chemical structure is more accurately characterised as a halogenated ether. The clinical use of methoxyflurane in human medicine has largely been abandoned because of detrimental effects on the kidneys, due to fluoride ions being produced by its metabolism in the kidney, and detrimental effects on the liver, including hepatic necrosis requiring liver transplant or causing death. The kidney effect was considered to be dose-dependent, smaller doses for shorter periods being considered relatively safer. The concurrent use of tetracyclines and methoxyflurane has been reported to result in fatal renal toxicity.

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