High Quality Content by WIKIPEDIA articles! Middlesex is a Pulitzer Prize-winning novel by Jeffrey Eugenides published in 2002. The book is a bestseller, with more than three million copies sold as of May 2011. Its characters and events are loosely based on aspects of Eugenides` life and observations of his Greek heritage. It is not an autobiography; Eugenides is not intersex like the protagonist. The author decided to write Middlesex after he read the 1980 memoir Herculine Barbin and was unsatisfied with its discussion of intersex anatomy and emotions.