High Quality Content by WIKIPEDIA articles! Miguel Angel Ondetti (May 14, 1930 – August 23, 2004) was an Argentinean-born American chemist that first synthesized captopril, the first ACE inhibitor that was used to treat heart disease. With his co-worker, David Cushman, he won the 1999 Lasker Award for: "developing an innovative approach to drug design based on protein structure and using it to create the ACE inhibitors, powerful oral agents for the treatment of high blood pressure, heart failure, and diabetic kidney disease”.