Modeling the Mechanics of Polymorphism in Bacterial Flagella. Development of a phenomenological model

Modeling the Mechanics of Polymorphism in Bacterial Flagella. Development of a phenomenological model

Srikanth Srigiriraju

     

бумажная книга



Издательство: Книга по требованию
Дата выхода: июль 2011
ISBN: 978-3-6391-0277-2
Объём: 204 страниц
Масса: 331 г
Размеры(В x Ш x Т), см: 23 x 16 x 2

Bacteria like Escherichia coli and Salmonella Typhimurium use flagella for locomotion. Each flagellum is run by a motor located in the cell body, with a long slender filament of 0.01-0.015mm long and 20nm in diameter attached to this motor. A swimming bacterium has all its filaments helical in shape involving a frequent change of their chirality, pitch and radius. To explain polymorphism, a new coarse-grained continuum rod theory with two molecular switches based on the quaternary structure of the filament is proposed. A phase diagram for filament shapes is calculated and the response of a filament to external moment and force is examined. To study the dynamics of the propagation of polymorphism in the filaments, a toy model with an external tensile shear fluid flow applied to a bistable cantilever 1D rod was modeled on the lines of phase transitions and simulations is performed using finite element techniques. Interesting results like nucleation of high-strain phase leading to either a trapped front separating two phases or uniform high-strain phase at steady state are observed.

Данное издание не является оригинальным. Книга печатается по технологии принт-он-деманд после получения заказа.