Modelling and analysis of nonnecrotic tumors. A Functional Analytic Approach

Modelling and analysis of nonnecrotic tumors. A Functional Analytic Approach

Anca-Voichita Matioc

     

бумажная книга



Издательство: Книга по требованию
Дата выхода: июль 2011
ISBN: 978-3-8381-1324-1
Объём: 140 страниц
Масса: 233 г
Размеры(В x Ш x Т), см: 23 x 16 x 1

Modelling and simulation of tumor growth is one of the challenging frontiers of applied mathematics. We study in this work a mathematical model for the growth of nonnecrotic tumors in different regimes of vascularisation. The tumor is treated as an incompressible fluid, tissue elasticity is neglected, and the mathematical model is a moving boundary problem. In the radially symmetric case we establish the existence of a unique radially symmetric stationary solution and show, that if the initial tumor is radially symmetric, there exists a unique radially symmetric solution of the problem, which exists for all times. The asymptotic behaviour of this solution it is also discussed. If we consider star-shaped initial tumor domains, we can re-express the mathematical model as an abstract evolution equation. Using general results for parabolic equations we prove the well-posedness of the model. The stability properties of the radially symmetric equilibrium are studied using the principle of linearised stability . Finally, we show, via a bifurcation argument, that there exist also other stationary solutions of the problem, which are no longer radially symmetric.

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