High Quality Content by WIKIPEDIA articles! A naive T cell or Th0 cell is a T cell that has differentiated in bone marrow, and successfully undergone the positive and negative processes of central selection in the thymus. A naive T cell is considered mature, but is distinguished from activated T cells or memory T cells, as it is thought not to have yet encountered cognate antigen in the periphery. Naive T cells are commonly characterized by the surface expression of L-selectin (CD62L); the absence of the activation markers CD25, CD44 or CD69; and the absence of memory markers, such as the edited CD45 isoforms. In the naive state, T cells are thought to be quiescent and non-dividing, requiring the common-gamma chain cytokines IL-7 and IL-15 for homeostatic survival.

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