High Quality Content by WIKIPEDIA articles! New York State Route 22 (NY 22) is a north–south state highway in eastern New York in the United States. It runs parallel to the state`s eastern edge from the outskirts of New York City to a short distance south of the Canadian border. At 341 miles (549 km), it is the state`s longest north–south route and the third longest overall, after NY 5 and NY 17. Many of the state`s major east–west roads intersect with Route 22 just before crossing the state line into the neighboring New England states.