High Quality Content by WIKIPEDIA articles! NSG, or NOD scid gamma, (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) is among the most immunodeficient strains of inbred laboratory mice described to date. NSG mice lack mature T cells, B cells, and natural killer (NK) cells. NSG mice are also deficient in multiple cytokine signaling pathways, and they have many defects in innate immunity. The compound immunodeficiencies in NSG mice permit the engraftment of a wide range of primary human cells, and enable sophisticated modeling of many areas of human biology and disease. NSG mice were developed in the laboratory of Dr. Leonard Shultz at The Jackson Laboratory.