High Quality Content by WIKIPEDIA articles! O Brother, Where Art Thou? is a 2000 comedy film written, produced, edited and directed by Joel and Ethan Coen and starring George Clooney, John Turturro, Tim Blake Nelson, and John Goodman, with Holly Hunter and Charles Durning in supporting roles. Set in 1937 rural Mississippi during the Great Depression, the film`s story is a modern satire loosely based on Homer’s Odyssey. The title of the film is a reference to the 1941 film Sullivan`s Travels, in which the protagonist (a director) wants to direct a film about the Great Depression called O Brother, Where Art Thou?