High Quality Content by WIKIPEDIA articles! The Office of Science is a component of the United States Department of Energy (DOE). The Office of Science is the lead federal agency supporting fundamental scientific research for energy and the Nation’s largest supporter of basic research in the physical sciences. The Office of Science portfolio has two principal thrusts: direct support of scientific research and direct support of the development, construction, and operation of unique, open-access scientific user facilities that are made available for use by external researchers.