High Quality Content by WIKIPEDIA articles! Orthomolecular medicine is a form of complementary and alternative medicine that seeks to maintain health and prevent or treat diseases by optimizing nutritional intake and/or prescribing supplements. The approach is sometimes referred to as megavitamin therapy as the practice evolved out of, and in some cases still uses, doses of vitamins and minerals many times higher than the recommended Dietary Reference Intake. Orthomolecular practitioners may also incorporate a variety of other treatment modalities into their approaches, including dietary restriction, megadoses of non-vitamin nutrients, and mainstream pharmaceutical drugs. Proponents believe that non-optimal levels of certain substances can cause health issues beyond simple deficiency and see balancing them as an integral part of health.