High Quality Content by WIKIPEDIA articles! A pancreaticoduodenectomy, pancreatoduodenectomy,Whipple procedure, or Kausch-Whipple procedure, is a major surgical operation involving the pancreas, duodenum, and other organs. This operation is performed to treat cancerous tumours on the head of the pancreas, malignant tumors involving common bile duct, duodenal papilla, or duodenum near the pancreas.