High Quality Content by WIKIPEDIA articles! Panosteitis is a common bone disease in dogs. It manifests with sudden, otherwise unexplained pain and lameness sometimes shifting from leg to leg, usually between 5 and 14 months of age. Signs such as fever and weight loss, and symptoms such as anorexia, and lethargy can also be seen. The cause is unknown, but genetics, stress, infection, metabolism, or an autoimmune component may be factors. It has also been suggested that rapid growth and high-protein food are involved in the pathogenesis.