Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. In epigenetics, paramutation is an interaction between two alleles of a single locus, resulting in a heritable change of one allele that is induced by the other allele. Paramutation violates Mendel's first law, which states that in the process of the formation of the gametes (egg or sperm) the allelic pairs separate, one going to each gamete, and that each allele remains completely uninfluenced by the other. In paramutation an allele in one generation heritably affects the other allele in future generations, even if the allele causing the change is itself not transmitted. What may be transmitted are patterns of DNA methylation or RNAs such as piRNAs, siRNAs, miRNAs or other regulatory RNAs. Through proper breeding, paramutation can result in isogenic sibling plants with drastically different phenotypes.

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