High Quality Content by WIKIPEDIA articles! The Passerini reaction is a chemical reaction involving an isocyanide, an aldehyde (or ketone), and a carboxylic acid to form a -acyloxy amide. This organic reaction was discovered by Mario Passerini in 1921 in Florence, Italy. It is the first multi-component reaction developed, and currently plays a central role in combinatorial chemistry.In polar solvents such as methanol or water, the reaction proceeds by protonation of the carbonyl followed by nucleophilic addition of the isocyanide to give the nitrilium ion 3. Addition of a carboxylate gives intermediate 4. Acyl group transfer and amide tautomerization give the desired ester 5.

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