High Quality Content by WIKIPEDIA articles! Pennsylvania Route 343 (designated by the Pennsylvania Department of Transportation as SR 0343) is an 8.21-mile (13.21 km) route between Lebanon, Pennsylvania and Fredericksburg, Pennsylvania. It begins at PA 72 and ends at Exit 6 of Interstate 78. State Route 343 heads mostly through urbanized areas, with several rural areas also surrounding. There is a concurrency with U.S. Route 22 near the northern terminus.