High Quality Content by WIKIPEDIA articles! Perfluorooctanesulfonamide (PFOSA) is a synthetic organofluorine compound. It is a fluorocarbon derivative, or perfluorinated compound, with eight carbons and a terminal sulfonamide functional group. PFOSA was an ingredient in 3M`s former Scotchgard formulation and the compound was used to repel grease and water in food packaging along with other consumer applications. It breaks down to form perfluorooctane sulfonate (PFOS). The perfluorooctanesulfonyl fluoride-based chemistry that was used to make sulfonamides like PFOSA was phased out by 3M in the United States (US) during 2000–2002 but it has grown in China by other producers.