High Quality Content by WIKIPEDIA articles! Phosphoinositide phospholipase C (PLC) (EC 3.1.4.11) is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. These enzymes belong to a larger superfamily of Phospholipase C. Other families of phospholipase C enzymes have been identified in bacteria and trypanosomes. Phospholipases C are phosphodiesterases.