High Quality Content by WIKIPEDIA articles! Pixantrone (6,9-bisbenzoisoquinoline-5,10-dione; rINN) is an experimental antineoplastic drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue. It acts as a topoisomerase II poison and intercalating agent. The code name BBR 2778 refers to pixantrone dimaleate, the actual substance commonly used in clinical trials.