High Quality Content by WIKIPEDIA articles! Point Accepted Mutation (PAM) or Percent Accepted Mutation, is a set of matrices used to score sequence alignments. The PAM matrices were introduced by Margaret Dayhoff in 1978 based on 1572 observed mutations in 71 families of closely related proteins. Each matrix is twenty-by-twenty (for the twenty standard amino acids); the value in a given cell represents the probability of a substitution of one amino acid for another. This type of matrix is commonly known as a substitution matrix. The PAM matrices imply a Markov chain model of protein mutation.

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