High Quality Content by WIKIPEDIA articles! The polar surface area (PSA) is defined as the surface sum over all polar atoms, (usually oxygen and nitrogen), including also attached hydrogens.PSA is a commonly used medicinal chemistry metric for the optimisation of cell permeability. Molecules with a polar surface area of greater than 140 angstroms squared are usually believed to be poor at permeating cell membranes. For molecules to penetrate the blood-brain barrier (and thus acting on receptors in the central nervous system), PSA should be less than 60 angstroms squared.

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