High Quality Content by WIKIPEDIA articles! Port Charles, New York is the fictional setting of the ABC Daytime soap operas General Hospital and its spin-offs Port Charles and General Hospital: Night Shift. It was revealed that the Queen`s Point setting of The Young Marrieds, a short-lived sister series to General Hospital that ran between 1964 and 1966, was a suburb of Port Charles. Locations within the town are described, below, using in-universe tone.