High Quality Content by WIKIPEDIA articles! The Prince Alfred (22 September 1780 – 20 August 1782) was a member of the British Royal Family as the fourteenth child and ninth son of King George III and his queen consort Charlotte of Mecklenburg-Strelitz. Alfred became ill after his inoculation from the smallpox virus; his early death at the age of nearly two, along with the demise of his brother Prince Octavius six months later, was a shock to their parents. In his later bouts of madness King George would have imagined conversations with both of his youngest sons.