High Quality Content by WIKIPEDIA articles! The first season of Prison Break, an American serial drama television series, commenced airing in the United States and Canada on August 29, 2005 on Mondays at 9:00 pm (EST) on the Fox Broadcasting Company. Prison Break is produced by Adelstein-Parouse Productions, in association with Rat Television, Original Television Movie and 20th Century Fox Television. The season contains 22 episodes, and concluded on May 15, 2006.