High Quality Content by WIKIPEDIA articles! The phenomenon of prohormone conversion was discovered by Donald F. Steiner while examining the biosynthesis of insulin in 1967. At the same time, while conducting chemical sequencing of ?-lipotrophic hormone (?LPH) with sheep pituitary glands Dr. Michel Chretien determined that the sequence of another hormone, Melanocyte-stimulating hormone ( ?MSH). This was the chemical evidence, at the level of primary protein sequence that peptide hormones could be found within larger protein molecules. The identity of the responsible enzymes was not clear for decades.

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