Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Prostacyclin (or PGI2) is a member of the family of lipid molecules known as eicosanoids. As a drug, it is also known as "epoprostenol". The terms are sometimes used interchangeably. During the 1960s, a U.K. research team, headed by Professor John Vane, who was later knighted for his contribution to science, began to explore the role of prostaglandins in anaphylaxis and respiratory diseases. Working with a team from the Royal College of Surgeons, Sir John discovered that aspirin and other oral anti-inflammatory drugs work by inhibiting the synthesis of prostaglandins. This critical finding opened the door to a broader understanding of the role of prostaglandins in the body. Sir John and a team from the Wellcome Foundation, had identified a lipid mediator they called “PG-X,” which inhibits platelet aggregation. PG-X, which later would become known as prostacyclin, is 30 times more potent than any other then-known anti-aggregatory agent.

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