High Quality Content by WIKIPEDIA articles! Pyrovalerone (Centroton, Thymergix, O-2371) is a psychoactive drug with stimulant effects via acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is used for the clinical treatment of chronic fatigue or lethargy and as an anorectic or appetite suppressant for weight loss purposes. It was developed in the late 1960s and has since been used in France and several other European countries. Though pyrovalerone is still occasionally prescribed, it is used infrequently due to problems with abuse and dependence. Pyrovalerone is a Schedule V controlled substance in the United States (U.S.), and is the only stimulant in that category. In Britain, it is in the Class C category and In Australia it is a Schedule 4 substance. It is closely related on a structural level to a number of other stimulants, such as MDPV and prolintane (Promotil, Katovit).