High Quality Content by WIKIPEDIA articles! RHC80267 is an inhibitor of diacylglycerol lipase. Diacylglycerol lipase generates the endocannabinoid 2-arachidonoylglycerol from diacylglycerol. Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. It catalyzes the hydrolysis of diacylglycerol releasing a free fatty acid and monoacylglycerol. Two separate genes encoding DGL enzymes have been cloned, termed DGL? (DAGLA) and DGL? (DAGLB), that share 33% sequence identity.

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