High Quality Content by WIKIPEDIA articles! A ? factor (Rho factor) is a prokaryotic protein involved in the termination of transcription. Rho factor is an essential transcription protein in prokaryotes. In Escherichia coli, it is a ~275 kD hexamer of identical subunits. Each subunit has an RNA-binding domain and an ATP-hydrolysis domain. Rho is a member of the family of ATP-dependent hexameric helicases that function by passing nucleic acids through the hole in the middle of the hexamer. Rho functions as an ancillary factor for RNA polymerase. Rho-dependent terminators account for about half of E. coli terminators. The other terminators discovered for E. coli are called Tau and nusA. Rho-dependent terminators were first discovered in bacteriophage genomes.

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