High Quality Content by WIKIPEDIA articles! Ro4-1539 (Furethylnorlevorphanol) is an opioid analgesic drug from the morphinan series, which was developed by the pharmaceutical company Hoffmann–La Roche in the 1950s. It acts as a potent ?-opioid agonist, and was found to be around 30-60x more potent than the related drug levorphanol in animal experiments. While it is notable for its high potency, being the most potent ?-agonist found in the morphinan series of drugs, Ro4-1539 had no particular clinical advantages over other available opioid drugs, and was never commercially marketed. Ro4-1539 has never been formally trialled in humans, but based on its effects in animals it would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and also respiratory depression which could be harmful or fatal.

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