High Quality Content by WIKIPEDIA articles! SAFE-BioPharma Association is the non-profit association that created and manages the SAFE-BioPharma digital identity and digital signature standard for the global pharmaceutical, biotech and healthcare industries. SAFE stands for "Signatures Authentication For Everyone". It was originally created as an initiative of the Pharmaceutical Research and Manufacturers of America (PhRMA) association to encourage the use of a common digital identity and digital signature standard for the pharmaceutical industry, but is now an independent non-profit association offering such standards services to the government and the entire healthcare industry.