High Quality Content by WIKIPEDIA articles! A Safety Instrumented System (SIS) is a form of process control usually implemented in industrial processes, such as those of a factory or an oil refinery. The SIS performs specified functions to achieve or maintain a safe state of the process when unacceptable or dangerous process conditions are detected. Safety instrumented systems are separate and independent from regular control systems but are composed of similar elements, including sensors, logic solvers, actuators and support systems.