Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Scavenger receptors are a group of receptors that recognize modified low-density lipoprotein (LDL) by oxidation or acetylation. This naming is based on a function of cleaning (scavenging): Scavenger receptors widely recognize and uptake macromolecules having a negative charge as well as modified LDL. It is thought that scavenger receptors participate in the removal of many foreign substances and waste materials in the living body by extensive ligand specificity and a variety of receptor molecules. In atherosclerotic lesions, macrophages that express scavenger receptors on their plasma membrane aggressively uptake the oxidized LDL deposited in the blood vessel wall inside and become foam cells, and they secrete various inflammatory cytokines and accelerate the development of atherosclerosis.

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