High Quality Content by WIKIPEDIA articles! Signed differential mapping or SDM is a statistical technique for meta-analyzing studies on differences in brain activity or structure which used neuroimaging techniques such as fMRI, VBM or PET. It may also refer to a specific piece of software created by the SDM Project to carry out such meta-analyses. SDM adopted and combined various positive features from previous methods, such as ALE or MKDA, and introduced a series of improvements and novel features. One of the new features, introduced to avoid positive and negative findings in the same voxel as seen in previous methods, was the representation of both positive differences and negative differences in the same map, thus obtaining a signed differential map (SDM).

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