Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. snoRNAs HBII-296A and B belong to the C/D family of snoRNAs. They are close paralogues sharing the same host gene (FLJ10534) and are predicted to guide 2'O-ribose methylation of the large 28S rRNA at position G4588. Small nucleolar RNAs (snoRNAs) are a class of small RNA molecules that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs which are associated with methylation, and the H/ACA box snoRNAs which are associated with pseudouridylation. snoRNAs are commonly referred to as guide RNAs but should not be confused with the guide RNAs that direct RNA editing in trypanosomes.

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