High Quality Content by WIKIPEDIA articles! Season ten of Smallville, an American television series, premiered on September 24, 2010 and consisted of 22 episodes. It was the tenth and final season to air, and the fifth one to air on The CW television network. The series recounts the early adventures of Kryptonian Clark Kent as he adjusts to life in the fictional town of Smallville, Kansas, during the years before he becomes Superman.