High Quality Content by WIKIPEDIA articles! Season six of Smallville, an American television series, began airing on September 28, 2006. The series recounts the early adventures of Kryptonian Clark Kent as he adjusts to life in the fictional town of Smallville, Kansas, during the years before he becomes Superman. The sixth season comprises 22 episodes and concluded its initial airing on May 17, 2007, marking the first season to air on the newly formed CW television network. Regular cast members during season six include Tom Welling, Kristin Kreuk, Michael Rosenbaum, Allison Mack, Annette O`Toole, John Glover, and Erica Durance.