High Quality Content by WIKIPEDIA articles! Sodium phenylbutyrate is an orphan drug, marketed by Ucyclyd Pharma under the trade name Buphenyl and by Swedish Orphan International as Ammonaps. It has been used to treat urea cycle disorders. Phenylbutyrate is a prodrug. In the human body it is metabolized by beta-oxidation to phenylacetate. Phenylacetate conjugate with glutamine to phenylacetylglutamine, that is eliminated with the urine. Sodium phenylbutyrate is also under investigation for the treatment of some sickle-cell disorders and for use as a potential differentiation-inducing agent in malignant glioma and acute myeloid leukaemia.

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