Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. In enzymology, a sorbitol-6-phosphate 2-dehydrogenase (EC 1.1.1.140) is an enzyme that catalyzes the chemical reaction D-sorbitol 6-phosphate + NAD+ rightleftharpoons D-fructose 6-phosphate + NADH + H+. Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NAD+, whereas its 3 products are D-fructose 6-phosphate, NADH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase. Other names in common use include ketosephosphate reductase, ketosephosphate reductase, D-sorbitol 6-phosphate dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, sorbitol-6-P-dehydrogenase, and D-glucitol-6-phosphate dehydrogenase. This enzyme participates in fructose and mannose metabolism.

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