High Quality Content by WIKIPEDIA articles! Stewart Gilligan "Stewie" Griffin is a fictional character from the animated television series Family Guy. Once obsessed with violence and matricide, Stewie (voiced by Seth MacFarlane) is the youngest child of Peter and Lois Griffin, and the brother of Chris and Meg. He also has a close friendship with the family`s anthropomorphic dog, Brian. He has a strong hatred for his mother Lois Griffin, as it is his lifelong goal to kill her.