High Quality Content by WIKIPEDIA articles! Structural variation (also genomic structural variation) is the variation in structure of an organism`s chromosome. It consists of many kinds of variation in the genome of one species, and usually includes microscopic and submicroscopic types, such as deletions, duplications, copy-number variants, insertions, inversions and translocations. Typically a structure variation affects a sequence length about 1Kb to 3Mb, which is larger than SNPs and smaller than chromosome abnormality (though the definition have some overlapping). The definition of structural variation do not imply about the frequency or phenotypical effects. Many of structural variants are associated with genetic diseases, however more are not. Recent research about SVs indicates that SVs are more difficult to detect than SNPs. SNPs always occur in two alleles, while approximately 5% of the human genome are defined as structurally variant in the normal population, involving more than 800 independent genes. Rapidly accumulating evidence indicates that structural variations can comprise millions of nucleotides of heterogeneity within every genome, and are likely to make an important contribution to human diversity and disease susceptibility.