High Quality Content by WIKIPEDIA articles! Sulfanilamide is a sulfonamide antibacterial. Chemically, it is a molecule containing the sulfonamide functional group attached to an aniline. As an antibiotic, it functions by competitively inhibiting (ie, by acting as a substrate analogue) enzymatic reactions involving para-aminobenzoic acid (PABA). PABA is needed in enzymatic reactions that produce folic acid which acts as a coenzyme in synthesis of things like purine, pyrimidine and other amino acids. Gerhard Domagk and Jacques and Therese Trefouel (1935) are generally credited with the discovery of sulfanilamide as a chemotherapeutic agent. Domagk was awarded the Nobel Prize for his work.

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