High Quality Content by WIKIPEDIA articles! The sixth season of Supernatural, an American television series, premiered on September 24, 2010, and concluded on May 20, 2011, airing 22 episodes. It is the fifth season to air on The CW television network. Regular cast members during season six include Jared Padalecki, Jensen Ackles, and Misha Collins. The season aired on Fridays at 9:00 pm (Eastern) in the United States on The CW.