Despite modern technology, little is known about brain function and its relationship to the underlying neuronal activities in the presence of a mental workload. This strongly stands when attempting to dissect the nature of the functional responses to inhibitory modulation in the brain.This book therefore presents a metabolomic approach to study inhibitory GABAergic neurotransmission using Nuclear Magnetic Resonance Spectroscopy. It encompasses a metabolic fingerprint which maps targeted activity of the GABAergic system using multivariate statistics. This book introduces a new approach to the study of brain function, a methodology which has great potential for use in high throughput screening of new pharmacological tools. This also provides a fundamental basis for the interpretation of in vivo pharmacological and functional magnetic resonance imaging studies: GABAergic modulation has distinct metabolic patterns which should be taken into account when evaluating functional imaging data involving modulation of neuronal inhibition.

Данное издание не является оригинальным. Книга печатается по технологии принт-он-деманд после получения заказа.