High Quality Content by WIKIPEDIA articles! The Lost Room is a 2006 science fiction television miniseries that aired on the Sci Fi Channel in the United States. The series revolves around the titular room and some of the everyday items from that room which possess unusual powers. The show`s protagonist, Joe Miller, is searching for these objects to rescue his daughter, Anna, who has disappeared inside the Room. Once a typical room at a 1960s motel along U.S. Route 66, the Lost Room has existed outside of normal time and space since 1961, when what is only referred to as "the Event" took place.