Ndrg-1 has been found to function as a metastasis suppressor in prostate, pancreatic, breast and other cancers. However, the molecular function of this elusive protein remains unknown. The aim of this study was to examine the function of Ndrg-1 in different cancer cells including prostate, lung and colon cancer. These studies reveal, for the first time, novel Ndrg-1 gene targets including Ccl2, Hod3, Thtpa, Fmo3 and VEGF. Ndrg-1 was also found to affect prostate cancer cell adhesion and proliferation. Furthermore, the ability of novel anti-cancer agents, the iron chelators, to up- regulate Ndrg-1 was also explored. Our results indicate that iron chelators are a promising new treatment strategy for cancer, partly due to their ability to increase cellular levels of this important metastasis suppressor protein.

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